CBD as an Anti-inflammatory Agent

CBD is widely known for its numerous health benefits including brain health, bone disease, and the ever-popular pain management. CBD’s Anti-inflammatory agent is incredible and benefits a large number of illnesses that involve inflammation.

There are many different types of products that contain CBD. CBD edibles, tinctures, topical wraps for skin, lotions, and creams are all currently on the market. You can also vaporize CBD oil, although, vaping is the fastest way to get CBD into the bloodstream. Research suggests that CBD can provide acute relief from inflammation, muscle soreness and joint pain when applied topically.

What is inflammation, and how it affects our body??

Inflammation is the natural way the body defends itself from illness. The immune system attacks anything that does not fit in your body in response to perceived danger and can even destroy your tissues. Self-damage is worth the sacrifice from your immune system if it can protect the entire body by preventing the disease from spreading.

You may perceive inflammation as heat discomfort, redness, swelling, and diminished function in places of your body. This is because the body enhances blood flow to the area through inflammation — and immune cells migrate into the tissue from the bloodstream to kill the danger and produce new cells. Inflammatory molecules orchestrate this cycle.

What research says about inflammation?

Researchers have correlated chronic inflammation to various diseases and health conditions over the past few decades. It is now believed that chronic inflammation affects up to 20 percent of cancer cases. Many health conditions, such as Alzheimer’s disease, are not generally caused by inflammation. Still, Alzheimer’s patients have increased inflammatory markers— and this inflammation raises the frequency and intensity of cognitive decline.


Although inflammation is necessary to help protect the body as it recovers, there is an unhealthy condition of persistent or recurrent inflammation that can be a cause of significant pain, distress, and is sometimes correlated with depression.

Although inflammation is necessary to help protect the body as it recovers, there is an unhealthy condition of persistent or recurrent inflammation that can be a cause of significant pain, distress, and is sometimes correlated with depression.

Studies have shown that CBD is an anti-inflammatory agent and can modulate the immune system. Although CBD has little interaction with cannabinoid receptors, CB1 and CB2, other receptors and targets are impacted. CBD binds to and easily desensitizes TRPV1 receptors. Pain and sensory experience, inflammation, and body temperature are known to mediate TRPV1 receptors.

Throughout animal models, CBD has been shown to relieve chronic inflammation, but again, not by explicitly communicating with cannabinoid receptors in the body.

Instead, CBD tends to inhibit chronic pain by interfering with another protein, the glycine receptor, which plays a vital role in the transmission of signals to the spinal cord and brain pain receptors.

Through reducing oxidative stress in the body, CBD and inflammation often work against each other. Oxidative stress happens when the development of free radicals and antioxidant defenses becomes disrupted, resulting in inflammation or harm to the tissue. CBD has antioxidant properties, and after successful chemotherapy treatment, it has been shown to reduce oxidative stress and inflammation in the body significantly. CBD is a greatly beneficial anti-inflammatory agent for any recovery from chemo or muscle strains.

Research-based evidence:

A 2017 research by Lippincott, Williams, and Wilkins in the journal Pain investigated the efficacy of CBD for inflammation in osteoarthritis male rats. Within two weeks, local CBD therapy was administered to the area where the intense inflammation of the joints occurred. CBD administration has also been shown to stop nerve damage and joint pain from arising.

CBD can affect a wide variety of molecules by activating the receptor, which asks the DNA to modify the genes it expresses. The medicinal efficacy of CBD for inflammation, Alzheimer’s disease, multiple sclerosis, and ulcerative colitis was related to the receptor, which concurrently decreases the development of inflammatory molecules while growing antioxidant production.

Using CBD as an anti-inflammatory agent was addressed in a 2015 study reported by Elsevier in Bioorganic and Medicinal Chemistry. The reviewers noticed that CBD reduces inflammation through several body mechanisms and is a significant potential treatment for a variety of inflammation-driven conditions.

A study published in PLoS One in 2011 examined the impact of CBD on acute and chronic intestinal inflammation. This sophisticated work was carried out on animal models of inflammation of the intestines and biopsies of ulcerative colitis patients. CBD has been shown to significantly combat inflammation and also to reduce bowel damage in mice and human biopsies by reducing inflammatory protein expression.

A study published by IOS Press in Clinical Hemorheology and Microcirculation in 2016 studied CBD for early pancreatic inflammation in diabetic mice. Due to an invasion of immune cells that kill insulin-producing cells, pancreatic inflammation may lead to diabetes. The mice that obtained ten weeks of CBD inflammation therapy developed diabetes faster than the mice who did not receive the medication and also showed a significant decrease in the stimulation of leukocytes. Leukocytes are a component of the immune system.

Scientists at the University of Mississippi Medical Center identified in research published in Free Radical Biology and Medicine not only the complications and difficulties presented by attempting to combat directly oxidative stress in a range of disease states, but also the advantages of using CBD to achieve this goal.

CBD has been shown to be particularly useful when dealing with different types of pain and inflammation. Many of the health-related problems associated with obesity are the result of increased inflammation. With the anticipation of raising some of these essential health effects, CBD is being widely studied in relation to obesity.


A significant body of scientific literature and anecdotal evidence now tends to support the use of CBD as an anti-inflammatory agent. Nevertheless, it is essential to keep in mind that many of these current studies have been preclinical and that human trials are needed to understand how CBD functions in humans properly.


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